2.3M hernia repairs in the US annually – one of the most common surgeries. $1B U.S. market for hernia repair devices. 9% growth supported by aging population and obesity epidemic. Market is dominated by synthetic polypropylene meshes, coated and uncoated. All synthetic meshes lack biocompatibility, resulting in complications, revisions, and cost escalation.

Top players by U.S. market share

  • R. Bard (Becton Dickinson) – 27%
  • LifeCell (Allergan) – 26%
  • Ethicon (J&J) – 19%
  • Covidien (Medtronic) – 17%

NanoAccel is a surface modification technology: it is not a coating and there are no additives.

NanoAccel has been applied to a variety of implant materials including metals (Ti, stainless steel, and cobalt chrome), polymers (PTFE, UHMWPE, PET and PEEK) as well as biologic materials (ligament, tendon, bone, and collagen).

Exogenesis has demonstrated improved cell adhesion, proliferation and differentiation in vitro on all surfaces and have in vivo data demonstrating osseointegration of PEEK.

In addition, NanoAccel can alter surfaces to:

  • promote soft tissue integration,
  • reduce biofilm formation,
  • promote the anti-adhesive property of surface to platelets while promoting endothelial cell attachment and proliferation, and
  • provide a superior controlled drug or protein eluting property without the use of polymers.

How does NanoAccel affect the surface?

NanoAccel technology provides the ability to alter and control many surface properties including:

  • texture at a nanoscale level 1,
  • charge 2,
  • crystallinity 3, and
  • hydrophilicity 4,

each of which is known from the literature to promote cell adhesion and proliferation.

  1. Dongwoo Khang, Jing Lu, Chang Yao, Karen M. Haberstroh, Thomas J. Webster, The role of nanometer and sub-micron surface features on vascular and bone cell adhesion on titanium, Biomaterials 29 (2008) 970-983.
  2. N.G. Marouda, Adhesion and spreading of cells on charged surfaces, Journal of Theoretical Biology, 49 (1975) 417-424.
  3. Soon-Eng Ong, Sam Zhang, Hejun Du, Yongsheng Wang, Lwin-Lwin Ma, In-vitro cellular behavior on amorphous carbon containing silicon, Thin Solid Films, 516 (2008) 5152-5156.
  4. T. Suzuki, N. Hori, W. Att, K. Kubo, F. Iwasa, T. Ueno, H. Maeda and T. Ogawa, Tissue Eng Pt A 15, (2009) pp.3679-3688.